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BDBM276757 2-(5-((3-ethoxypyridin- 2-yl)oxy)pyridin-3-yl)- N-(2-methyl-1-(methyl- sulfonyl)propan-2-yl) pyrimidine-5-carboxamide::US10071992, Example 3.6

SMILES: CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)S(C)(=O)=O

InChI Key: InChIKey=KHXPARUTHKQJQB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 276757   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM276757
PNG
(2-(5-((3-ethoxypyridin- 2-yl)oxy)pyridin-3-yl)- N-...)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C21H23N5O5S/c1-5-30-17-7-6-8-23-20(17)31-16-9-14(10-22-13-16)18-24-11-15(12-25-18)19(27)26-21(2,3)32(4,28)29/h6-13H,5H2,1-4H3,(H,26,27)
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KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35.4n/an/an/an/a7.425



Pfizer Inc

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)


Article DOI: 10.1016/j.bmcl.2005.11.048
BindingDB Entry DOI: 10.7270/Q2RJ4MHN
More data for this
Ligand-Target Pair