BDBM276788 7-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}pyrido[3,2-d]pyrimidin-4-amine::US10071998, Example 3
SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F
InChI Key InChIKey=OQRKAIXNIOZZEN-SFHVURJKSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 276788
Affinity DataKi: 0.810nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
Affinity DataKi: 2.80nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair