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BDBM2785 Alkenyldiarylmethane (ADAM) 27a::Alkenyldiarylmethanes (ADAM) 27a::Isopropyl 3,3-Dibromo-4,4-dimethoxy-5,5-bis(methoxycarbonyl)-6,6-diphenyl-5-hexenoate::methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxycarbonyl)phenyl]-6-oxo-6-(propan-2-yloxy)hex-1-en-1-yl}-2-methoxybenzoate

SMILES: [#6]-[#8]-[#6](=O)-c1cc(cc(Br)c1-[#8]-[#6])-[#6](=[#6]/[#6]-[#6]-[#6]-[#6](=O)-[#8]-[#6](-[#6])-[#6])\c1cc(Br)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6]

InChI Key: InChIKey=RZBIETXDVPBASJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2785   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2785
PNG
(Alkenyldiarylmethane (ADAM) 27a | Alkenyldiarylmet...)
Show SMILES COC(=O)c1cc(cc(Br)c1OC)C(=CCCCC(=O)OC(C)C)c1cc(Br)c(OC)c(c1)C(=O)OC
Show InChI InChI=1S/C27H30Br2O8/c1-15(2)37-23(30)10-8-7-9-18(16-11-19(26(31)35-5)24(33-3)21(28)13-16)17-12-20(27(32)36-6)25(34-4)22(29)14-17/h9,11-15H,7-8,10H2,1-6H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.08E+4n/an/an/an/an/an/a



Purdue University



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 44: 4092-113 (2001)


Article DOI: 10.1021/jm010212m
BindingDB Entry DOI: 10.7270/Q2XG9PB0
More data for this
Ligand-Target Pair