BDBM278616 (2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 78

SMILES Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2ccc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12

InChI Key InChIKey=QKDGUBMFMNBEAM-RMKNXTFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278616   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278616((2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(3- methylox...)
Affinity DataIC50:  192nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278616((2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(3- methylox...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent