BDBM27879 4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydropyridin-2-one::BMS-536924::CHEMBL401930::US10710978, Compound BMS536924

SMILES: Cc1cc(cc2c1nc([nH]2)C3=C(C=CNC3=O)NC[C@H](c4cccc(c4)Cl)O)N5CCOCC5

InChI Key: InChIKey=ZWVZORIKUNOTCS-UHFFFAOYSA-N

Data: 33 IC50

PDB links: 6 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 27879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Mouse)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	7.0	30
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Focal adhesion kinase 1 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM27879 (CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	7.4	37
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