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BDBM279011 N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 41::US10512632, Example 41::US10618913, Example S41

SMILES: CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C

InChI Key: InChIKey=CAHURFTWFHHOPU-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 279011   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)


BindingDB Entry DOI: 10.7270/Q2X350HN
More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 45n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)


BindingDB Entry DOI: 10.7270/Q2X350HN
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)


BindingDB Entry DOI: 10.7270/Q2X350HN
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10512632 (2019)


BindingDB Entry DOI: 10.7270/Q25T3NVN
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...


US Patent US10618913 (2020)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10512632 (2019)


BindingDB Entry DOI: 10.7270/Q25T3NVN
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...


US Patent US10618913 (2020)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 45n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...


US Patent US10618913 (2020)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 45n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10512632 (2019)


BindingDB Entry DOI: 10.7270/Q25T3NVN
More data for this
Ligand-Target Pair