BDBM27943 uridine derivative, 39::{[(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(F)c(=O)[nH]c1=O

InChI Key InChIKey=RNBMPPYRHNWTMA-UAKXSSHOSA-N

Data  2 KI

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27943   

TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
Toronto General Research Institute

LigandPNGBDBM27943(uridine derivative, 39 | {[(2R,3S,4R,5R)-5-(5-fluo...)
Affinity DataKi:  9.80E+4nM ΔG°:  -5.68kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
Toronto General Research Institute

LigandPNGBDBM27943(uridine derivative, 39 | {[(2R,3S,4R,5R)-5-(5-fluo...)
Affinity DataKi:  6.45E+5nM ΔG°:  -4.79kcal/molepH: 7.5 T: 2°CAssay Description:An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...More data for this Ligand-Target Pair