BDBM28031 BMS-777607::N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

SMILES: CCOC1=C(C(=O)N(C=C1)c2ccc(cc2)F)C(=O)Nc3ccc(c(c3)F)Oc4ccnc(c4Cl)N

InChI Key: InChIKey=VNBRGSXVFBYQNN-UHFFFAOYSA-N

Data: 35 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 28031   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Macrophage-stimulating protein receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aurora kinase B (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Insulin receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Platelet-derived growth factor receptor alpha (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	594	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM28031 (N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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