BDBM280348 N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]pyridine-3-carboxamide::US10030004, Compound 15::US10501436, Compound 15::US11053216, Compound 15::US11702401, Compound 15

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(N)=O)-c1cc(Cl)ccc1F

InChI Key InChIKey=YJKNBYBEJYUUHW-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 280348   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  4.59E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  15.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.54E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  11.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  15.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  4.59E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.14E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.54E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  11.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  15.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  4.59E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.14E+4nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.54E+4nMMore data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  11.7nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  15.5nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  4.59E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.14E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.54E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  11.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280348(N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chloro-2-fluoro-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.14E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI