BDBM280351 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-(methane sulfonamido)ethyl]pyridine-3-carboxamide::US10030004, Compound 18::US10501436, Compound 18::US11053216, Compound 18::US11702401, Compound 18

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NCCNS(C)(=O)=O)-c1cc(Cl)ccc1F

InChI Key InChIKey=ATSRJSICZUBQJU-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280351   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  105nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  34.5nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  6.92E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  105nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  34.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280351(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI