BDBM280362 N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-yl)pyridin-4-yl]amino} pyridine-3-carboxamide::US10030004, Compound 28::US11053216, Compound 28::US11702401, Compound 28

SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1

InChI Key InChIKey=XDHZSOHHUNDLNQ-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280362   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  551nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  1.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  551nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50:  551nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280362(N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent