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BDBM28067 (4Z)-6-[(3-aminophenyl)amino]-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione::isoquinolinedione, 22

SMILES: Nc1cccc(Nc2ccc3C(=O)NC(=O)C(=CNc4ccc(CN5CCCCC5)cc4)c3c2)c1

InChI Key: InChIKey=RPWXWUYNBKZAJU-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28067   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM28067
PNG
((4Z)-6-[(3-aminophenyl)amino]-4-({[4-(piperidin-1-...)
Show SMILES Nc1cccc(Nc2ccc3C(=O)NC(=O)C(=CNc4ccc(CN5CCCCC5)cc4)c3c2)c1
Show InChI InChI=1S/C28H29N5O2/c29-20-5-4-6-22(15-20)31-23-11-12-24-25(16-23)26(28(35)32-27(24)34)17-30-21-9-7-19(8-10-21)18-33-13-2-1-3-14-33/h4-12,15-17,30-31H,1-3,13-14,18,29H2,(H,32,34,35)
PDB
MMDB

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Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.522



Wyeth Research



Assay Description
Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...


Bioorg Med Chem Lett 18: 3641-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.044
BindingDB Entry DOI: 10.7270/Q2QR4VFD
More data for this
Ligand-Target Pair