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BDBM281185 US10022354, Example 125

SMILES: CC(C)CC(=O)NC1CCN(C1)C(=O)c1cc(n[nH]1)C(C)C

InChI Key: InChIKey=IJBOJLLGNQPJTF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281185
PNG
(US10022354, Example 125)
Show SMILES CC(C)CC(=O)NC1CCN(C1)C(=O)c1cc(n[nH]1)C(C)C
Show InChI InChI=1S/C16H26N4O2/c1-10(2)7-15(21)17-12-5-6-20(9-12)16(22)14-8-13(11(3)4)18-19-14/h8,10-12H,5-7,9H2,1-4H3,(H,17,21)(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/a7.025



Genentech Inc

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)


BindingDB Entry DOI: 10.7270/Q2PC34F7
More data for this
Ligand-Target Pair