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BDBM281294 US10022354, Example 234::US10022354, Example 237

SMILES: CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1

InChI Key: InChIKey=GTOUGEUJJURULS-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281294   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281294
PNG
(US10022354, Example 234 | US10022354, Example 237)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1
Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/a7.025



Genentech Inc

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)


BindingDB Entry DOI: 10.7270/Q2PC34F7
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281294
PNG
(US10022354, Example 234 | US10022354, Example 237)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1
Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.160n/an/an/an/a7.025



Genentech Inc

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)


BindingDB Entry DOI: 10.7270/Q2PC34F7
More data for this
Ligand-Target Pair