BDBM281294 US10022354, Example 234::US10022354, Example 237

SMILES: CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1

InChI Key: InChIKey=GTOUGEUJJURULS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM281294 (US10022354, Example 234 | US10022354, Example 237) Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1 Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	7.0	25
Genentech Inc US Patent					Assay Description Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...				US Patent US10022354 (2018) BindingDB Entry DOI: 10.7270/Q2PC34F7
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM281294 (US10022354, Example 234 | US10022354, Example 237) Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1 Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.0	25
Genentech Inc US Patent					Assay Description Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...				US Patent US10022354 (2018) BindingDB Entry DOI: 10.7270/Q2PC34F7
					More data for this Ligand-Target Pair