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BDBM281500 N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxazol- 6-yl)-2- chloropyridin-3- yl)ethanesulfonamide::US10022387, Example 26::US9586949, Example 26

SMILES: CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1

InChI Key: InChIKey=AGUINAIUNUSINO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281500   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
PDB
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PC sid
UniChem
Article
US Patent
n/an/a<250n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US9586949 (2017)


Article DOI: 10.1016/j.bmcl.2004.09.053
BindingDB Entry DOI: 10.7270/Q2MP5593
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a>5.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10022387 (2018)


Article DOI: 10.1021/jm060666p
BindingDB Entry DOI: 10.7270/Q2DZ0BBM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
PDB
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a<250n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase...


US Patent US10022387 (2018)


Article DOI: 10.1021/jm060666p
BindingDB Entry DOI: 10.7270/Q2DZ0BBM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM281500
PNG
(N-(5-(2-(1H- Benzo[d]imidazol- 2 - yl)benzo[d]oxaz...)
Show SMILES CCS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2nc(oc2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H16ClN5O3S/c1-2-31(28,29)27-17-9-13(11-23-19(17)22)12-7-8-16-18(10-12)30-21(26-16)20-24-14-5-3-4-6-15(14)25-20/h3-11,27H,2H2,1H3,(H,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a>5.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US9586949 (2017)


Article DOI: 10.1016/j.bmcl.2004.09.053
BindingDB Entry DOI: 10.7270/Q2MP5593
More data for this
Ligand-Target Pair