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BDBM281640 US10022461, Compound 110

SMILES: Nc1c(F)ccc2cc(ncc12)-n1ccc2ccncc12

InChI Key: InChIKey=DQZQYSQUTOJZLI-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281640   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281640
PNG
(US10022461, Compound 110)
Show SMILES Nc1c(F)ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-2-1-11-7-15(20-8-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.15 -11.8n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)


Article DOI: 10.1074/jbc.M413155200
BindingDB Entry DOI: 10.7270/Q2959KK6
More data for this
Ligand-Target Pair