BDBM282572 (R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy- 1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)- 5-fluorobenzonitrile::US9884843, Compound 3::US9884843, Compound 43

SMILES: c1cc2c(c(c1Oc3cc(cc(c3)F)C#N)C(F)F)[C@H](C(S2(=O)=O)(F)F)O

InChI Key: InChIKey=HZDKYXAZAPXCKQ-UHFFFAOYSA-N

Data: 9 IC50  5 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 282572   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor A (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	7.5	n/a
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Vascular endothelial growth factor A (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	7.5	n/a
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Vascular endothelial growth factor A (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor A (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	145	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2B6 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
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