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BDBM282910 6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoropropyl)-1H-imidazol-5-yl)imidazo[1,2- b]pyridazine-3-carboxamide::US9884868, Example 115'

SMILES: CCc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1cccc(C)c1

InChI Key: InChIKey=QRRYAIVGAHXSHB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282910   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM282910
PNG
(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoro...)
Show SMILES CCc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1cccc(C)c1
Show InChI InChI=1S/C18H17N5/c1-3-15-21-17(13-6-4-5-12(2)9-13)18(22-15)14-7-8-16-19-11-20-23(16)10-14/h4-11H,3H2,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a>1.50E+4n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent




US Patent US9884868 (2018)


Article DOI: 10.1021/jm0499108
BindingDB Entry DOI: 10.7270/Q20P122M
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM282910
PNG
(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoro...)
Show SMILES CCc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1cccc(C)c1
Show InChI InChI=1S/C18H17N5/c1-3-15-21-17(13-6-4-5-12(2)9-13)18(22-15)14-7-8-16-19-11-20-23(16)10-14/h4-11H,3H2,1-2H3,(H,21,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4.60n/an/an/an/a7.425



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...


US Patent US9884868 (2018)


Article DOI: 10.1021/jm0499108
BindingDB Entry DOI: 10.7270/Q20P122M
More data for this
Ligand-Target Pair