BDBM282910 6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoropropyl)-1H-imidazol-5-yl)imidazo[1,2- b]pyridazine-3-carboxamide::US9884868, Example 115'

SMILES CCc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1cccc(C)c1

InChI Key InChIKey=QRRYAIVGAHXSHB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282910   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282910(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoro...)
Affinity DataIC50: >1.50E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282910(6-(4-(3-chloro-4-fluorophenyl)-1-(3,3,3- trifluoro...)
Affinity DataIC50:  4.60nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent