BDBM283527 N-((4,6-dimethyl-2,3-dihydro-1H-pyrrolo[2,3- b]pyridin-5-yl)methyl)-2-((3- (trifluoromethyl)quinolin-6- yl)methyl)isonicotinamide::US10023557, Example 176::US10308637, Example 176

SMILES Cc1nc2NCCc2c(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(cc3c2)C(F)(F)F)c1

InChI Key InChIKey=VVONGBLBROSHAM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 283527   

TargetPlasma kallikrein(Homo sapiens (Human))
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283527(N-((4,6-dimethyl-2,3-dihydro-1H-pyrrolo[2,3- b]pyr...)
Affinity DataIC50: <100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283527(N-((4,6-dimethyl-2,3-dihydro-1H-pyrrolo[2,3- b]pyr...)
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283527(N-((4,6-dimethyl-2,3-dihydro-1H-pyrrolo[2,3- b]pyr...)
Affinity DataEC50:  550nMAssay Description:The test compounds at various concentrations, also prepared by serial dilutions as described above, are added to the test wells. The volume of test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent