BDBM283657 N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- (piperidin-1-yl)quinolin-6- yl)methyl)isonicotinamide::US10023557, Example 303::US10308637, Example 303

SMILES Nc1nccc2cc(CNC(=O)c3ccnc(Cc4ccc5ncc(cc5c4)N4CCCCC4)c3)ccc12

InChI Key InChIKey=CYJWRCPBQNZAPJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283657   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283657(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- (piperi...)
Affinity DataIC50:  5.50E+3nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283657(N-((1-aminoisoquinolin-6-yl)methyl)-2-((3- (piperi...)
Affinity DataIC50:  5.50E+3nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent