BDBM284068 6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylacetyl)piperazin-1- yl)pyridin-3-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US10023570, Example 78::US10174027, Example 78

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccccc2)c2c(cnn2c1)C#N

InChI Key InChIKey=KWZLPYIQALPLFA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284068   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284068(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylac...)
Affinity DataIC50:  4.40nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284068(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylac...)
Affinity DataIC50:  4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284068(6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylac...)
Affinity DataIC50:  4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent