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BDBM28413 (2E)-3-[3-(6-{[3-(dimethylamino)propyl](methyl)amino}pyrazin-2-yl)phenyl]prop-2-enoic acid::pyrazine inhibitor, 17

SMILES: CN(C)CCCN(C)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1

InChI Key: InChIKey=VMOVXVNJYAUUIB-CMDGGOBGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28413   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28413
PNG
((2E)-3-[3-(6-{[3-(dimethylamino)propyl](methyl)ami...)
Show SMILES CN(C)CCCN(C)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H24N4O2/c1-22(2)10-5-11-23(3)18-14-20-13-17(21-18)16-7-4-6-15(12-16)8-9-19(24)25/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,24,25)/b9-8+
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 370n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair