BDBM284460 4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyridin-3-yl)-6-(1-methyl-1H- pyrazol-4-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US10023570, Example 470::US10174027, Example 470

SMILES Cc1cccc(C)c1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=JLNYAMNVONSEGP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284460   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  99.2nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  397nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  397nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  397nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  99.2nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM284460(4-(6-(4-(2,6- dimethylbenzyl)piperazin-1- yl)pyrid...)
Affinity DataIC50:  99.2nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent