BDBM284469 6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(oxetan-3- yl)piperazin-l-yl)pyridin- 3-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US10023570, Example 479::US10174027, Example 479

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C2COC2)c2c(cnn2c1)C#N

InChI Key InChIKey=KEMHXWWOVJQIOS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284469   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 49.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 49.3nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 49.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 374nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 374nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284469(US10023570, Example 479 | 6-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 374nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent