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BDBM284969 2-methyl-4-(3-morpholin-4-yl- sulfonylphenyl)isoquinolin-1-one::US10023592, Example 14

SMILES: Cn1cc(-c2cccc(c2)S(=O)(=O)N2CCOCC2)c2ccccc2c1=O

InChI Key: InChIKey=CVEZVFBZBAPJHP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 284969   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM284969
PNG
(2-methyl-4-(3-morpholin-4-yl- sulfonylphenyl)isoqu...)
Show SMILES Cn1cc(-c2cccc(c2)S(=O)(=O)N2CCOCC2)c2ccccc2c1=O
Show InChI InChI=1S/C20H20N2O4S/c1-21-14-19(17-7-2-3-8-18(17)20(21)23)15-5-4-6-16(13-15)27(24,25)22-9-11-26-12-10-22/h2-8,13-14H,9-12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.75E+3n/an/an/an/a7.3n/a



Celgene Quanticel Research Inc

US Patent


Assay Description
Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...


US Patent US10023592 (2018)


Article DOI: 10.1021/jm0303406
BindingDB Entry DOI: 10.7270/Q2668G7H
More data for this
Ligand-Target Pair