BDBM285029 N-[3-(2-methyl-1-oxo-6-phenylisoquinolin- 4-yl)phenyl]methanesulfonamide::US10023592, Example 74

SMILES Cn1cc(-c2cccc(NS(C)(=O)=O)c2)c2cc(ccc2c1=O)-c1ccccc1

InChI Key InChIKey=PSPDBKYBDYJXRN-UHFFFAOYSA-N

Data  2 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285029   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM285029(N-[3-(2-methyl-1-oxo-6-phenylisoquinolin- 4-yl)phe...)
Show SMILES Cn1cc(-c2cccc(NS(C)(=O)=O)c2)c2cc(ccc2c1=O)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3S/c1-25-15-22(18-9-6-10-19(13-18)24-29(2,27)28)21-14-17(11-12-20(21)23(25)26)16-7-4-3-5-8-16/h3-15,24H,1-2H3
Affinity DataIC50: 920nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM285029(N-[3-(2-methyl-1-oxo-6-phenylisoquinolin- 4-yl)phe...)
Show SMILES Cn1cc(-c2cccc(NS(C)(=O)=O)c2)c2cc(ccc2c1=O)-c1ccccc1
Show InChI InChI=1S/C23H20N2O3S/c1-25-15-22(18-9-6-10-19(13-18)24-29(2,27)28)21-14-17(11-12-20(21)23(25)26)16-7-4-3-5-8-16/h3-15,24H,1-2H3
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid