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BDBM285062 3-amino-1-methyl-5-(3- methylsulfonylphenyl)pyridin-2-one::US10023592, Example 107

SMILES: Cn1cc(cc(N)c1=O)-c1cccc(c1)S(C)(=O)=O

InChI Key: InChIKey=YGUMCEDDFVYQNX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285062   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM285062
PNG
(3-amino-1-methyl-5-(3- methylsulfonylphenyl)pyridi...)
Show SMILES Cn1cc(cc(N)c1=O)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C13H14N2O3S/c1-15-8-10(7-12(14)13(15)16)9-4-3-5-11(6-9)19(2,17)18/h3-8H,14H2,1-2H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/a7.3n/a



Celgene Quanticel Research Inc

US Patent


Assay Description
Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...


US Patent US10023592 (2018)


BindingDB Entry DOI: 10.7270/Q2668G7H
More data for this
Ligand-Target Pair