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BDBM285064 N-[5-(5-amino-1-methyl-6-oxopyridin-3-yl)-2- methoxyphenyl]methanesulfonamide::US10023592, Example 109

SMILES: COc1ccc(cc1NS(C)(=O)=O)-c1cc(N)c(=O)n(C)c1

InChI Key: InChIKey=IXKHTLKKEDXCEF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285064   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM285064
PNG
(N-[5-(5-amino-1-methyl-6-oxopyridin-3-yl)-2- metho...)
Show SMILES COc1ccc(cc1NS(C)(=O)=O)-c1cc(N)c(=O)n(C)c1
Show InChI InChI=1S/C14H17N3O4S/c1-17-8-10(6-11(15)14(17)18)9-4-5-13(21-2)12(7-9)16-22(3,19)20/h4-8,16H,15H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 2.75E+3n/an/an/an/a7.3n/a



Celgene Quanticel Research Inc

US Patent


Assay Description
Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...


US Patent US10023592 (2018)


Article DOI: 10.1021/jm0303406
BindingDB Entry DOI: 10.7270/Q2668G7H
More data for this
Ligand-Target Pair