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BDBM286226 3-cyclopropyl-6-fluoro-2- (pyridin-3-yl)imidazo[1,2- a]pyridine::US9518055, Example 28

SMILES: Fc1ccc2nc(c(C3CC3)n2c1)-c1cccnc1

InChI Key: InChIKey=JZHFBFYLCYWYRN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286226   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B1, mitochondrial


(Homo sapiens (Human))
BDBM286226
PNG
(3-cyclopropyl-6-fluoro-2- (pyridin-3-yl)imidazo[1,...)
Show SMILES Fc1ccc2nc(c(C3CC3)n2c1)-c1cccnc1
Show InChI InChI=1S/C15H12FN3/c16-12-5-6-13-18-14(11-2-1-7-17-8-11)15(10-3-4-10)19(13)9-12/h1-2,5-10H,3-4H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 76n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...


US Patent US9518055 (2016)


BindingDB Entry DOI: 10.7270/Q23B625B
More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM286226
PNG
(3-cyclopropyl-6-fluoro-2- (pyridin-3-yl)imidazo[1,...)
Show SMILES Fc1ccc2nc(c(C3CC3)n2c1)-c1cccnc1
Show InChI InChI=1S/C15H12FN3/c16-12-5-6-13-18-14(11-2-1-7-17-8-11)15(10-3-4-10)19(13)9-12/h1-2,5-10H,3-4H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.4n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...


US Patent US9518055 (2016)


BindingDB Entry DOI: 10.7270/Q23B625B
More data for this
Ligand-Target Pair