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BDBM286445 US9518064, Example 61

SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OCc3ccc(OC)cc3)cc(OC)cc2o1

InChI Key: InChIKey=URNNTQADHDAVFL-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 286445   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM286445
PNG
(US9518064, Example 61)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OCc3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1/C36H32N4O6S/c1-22(44-20-23-8-11-27(41-2)12-9-23)26-10-13-30(37-18-26)25-7-5-6-24(14-25)21-45-32-15-28(42-3)16-33-29(32)17-34(46-33)31-19-40-35(38-31)47-36(39-40)43-4/h5-19,22H,20-21H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1n/an/an/an/an/a25



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2TT4SZX
More data for this
Ligand-Target Pair