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BDBM286871 (S)-1-[8-Chloro-3-(5- chloro-2-ethanesulfonyl- benzyl)-2,4-dioxo-6- trifluoromethyl-1,2,3,4- tetrahydro-quinazolin-7- ylmethyl]-pyrrolidine-2- carboxylic acid methylamide::US9567304, Compound F-146

SMILES: CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCC[C@H]3C(=O)NC)c(cc2c1=O)C(F)(F)F

InChI Key: InChIKey=SVLVBGHYJXJPBK-LGWFVXIRNA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 286871   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM286871
PNG
((S)-1-[8-Chloro-3-(5- chloro-2-ethanesulfonyl- ben...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCC[C@H]3C(=O)NC)c(cc2c1=O)C(F)(F)F
Show InChI InChI=1/C25H25Cl2F3N4O5S/c1-3-40(38,39)19-7-6-14(26)9-13(19)11-34-23(36)15-10-17(25(28,29)30)16(20(27)21(15)32-24(34)37)12-33-8-4-5-18(33)22(35)31-2/h6-7,9-10,18H,3-5,8,11-12H2,1-2H3,(H,31,35)(H,32,37)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 410n/an/an/an/an/a25



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)


Article DOI: 10.1016/j.bmc.2004.11.045
BindingDB Entry DOI: 10.7270/Q2FN1871
More data for this
Ligand-Target Pair