BDBM28706 2-methyl-2-phenoxypropanoic acid, 25a::2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}formamido)methyl]phenoxy}propanoic acid::CHEMBL219586

SMILES Cc1nc(sc1C(=O)NCc1ccc(OC(C)(C)C(O)=O)cc1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=ILUPZUOBHCUBKB-UHFFFAOYSA-N

Data  1 Kd  21 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 28706   

LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataKd:  170nMAssay Description:Binding affinity to His-tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) at 25 degree C by isothermal titration calo...More data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  9.70E+3nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  9.70E+3nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPARalpha receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  2.83E+3nMAssay Description:Agonist activity at human PPARdelta receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  9.71E+3nMAssay Description:Agonist activity at human PPARgamma receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  2.60E+3nMAssay Description:Transactivation of GAL4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  10nMAssay Description:Transactivation of GAL4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Transactivation of GAL4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human PPARalpha-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human PPARgamma-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at human PPARdelta-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPARalphaMore data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PPARalpha after 22 to 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human PPARalpha expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity incubated for 22 ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28706(2-methyl-2-phenoxypropanoic acid, 25a | 2-methyl-2...)
Affinity DataEC50:  2.83E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed