BDBM28754 2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}methyl)sulfanyl]phenoxy}propanoic acid::reverse-[1,2,4]thiadiazole derivative, 41

SMILES Cc1cc(SCc2nsc(n2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O

InChI Key InChIKey=RJFFDLMVDVMUFD-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 28754   

TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  425nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50: >3.00E+3nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  425nMAssay Description:Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM28754(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  26nMAssay Description:The confluent HEK293 cells were co-transfected with DNA construct containing PPARdelta-Gal4 chimeric receptor and Gal4-luciferase reporter. The lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed