BDBM287812 6-[(8,8- difluorobicyclo[3.2.1]oct- 3-yl)carbonyl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 30::US10086000, Example 67::US10508108, Example 67

SMILES FC1(F)C2CCC1CC(C2)C(=O)N1Cc2cccnc2Nc2ccccc12

InChI Key InChIKey=VZYNKLSHDTXNNA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287812   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287812(US10086000, Example 30 | 6-[(8,8- difluorobicyclo[...)
Affinity DataIC50: 1.77E+3nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287812(US10086000, Example 30 | 6-[(8,8- difluorobicyclo[...)
Affinity DataIC50: 1.77E+3nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287812(US10086000, Example 30 | 6-[(8,8- difluorobicyclo[...)
Affinity DataIC50: 1.77E+3nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287812(US10086000, Example 30 | 6-[(8,8- difluorobicyclo[...)
Affinity DataIC50: 1.77E+3nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent