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BDBM288254 5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7-::US10087185, Example 72

SMILES: CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F

InChI Key: InChIKey=NSYWXBHQQAJBQZ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288254   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288254
PNG
(5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...)
Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N3O/c1-9(2)15-8-12-3-4-13(19(21,22)23)18(26(12)25-15)11-5-10-7-16(27)24-17(10)14(20)6-11/h3-6,8-9H,7H2,1-2H3,(H,24,27)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0130n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)


BindingDB Entry DOI: 10.7270/Q2QZ2D0H
More data for this
Ligand-Target Pair