BDBM288423 5-[8-amino-1-(4- {[4- (trifluoromethyl) pyridin-2- yl]carbamoyl} phenyl)imidazo[1,5- a]pyrazin-3- yl]furan-2- carboxylic acid::US10087188, Example 28

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)-c1ccc(o1)C(O)=O

InChI Key InChIKey=BNGYEVZYURCTJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288423   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM288423(5-[8-amino-1-(4- {[4- (trifluoromethyl) pyridin-2-...)
Affinity DataIC50:  2.40nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent