BDBM289613 6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10092575, Example 101::US10376514, Example 101

SMILES CN1CCc2c(C1)sc1n(Cc3ccc(Cl)cc3)c(=O)n3ncnc3c21

InChI Key InChIKey=AXPVGJNPJSMCLA-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 289613   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  550nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataEC50:  550nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  550nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed