BDBM289850 N—((S)-1-((R)-6-chloro-5-fluoro-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,3′-piperidin]-1′-yl)-1-oxo-3-phenylpropan-2-yl)-3-(trifluoromethyl)-1H-indazole-5-carboxamide::US10093683, Example 256

SMILES Fc1c(Cl)ccc2NC(=O)O[C@]3(CCCN(C3)C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc4[nH]nc(c4c3)C(F)(F)F)c12

InChI Key

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289850   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM289850(N—((S)-1-((R)-6-chloro-5-fluoro-2-oxo-1,2-dih...)
Affinity DataKi: >875nM ΔG°: >-8.26kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent