BDBM29012 N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlorobenzene)sulfonamido}pentyl]-N-methylmethanesulfonamide::Nitrogen-appended N-alkylsulfonamide, 1
SMILES C[C@H](CCCN(C)S(C)(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
InChI Key InChIKey=CPXMPFPTEVZISR-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 29012
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb
Bristol-Myers Squibb
Affinity DataEC50: 0.320nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair