BDBM290601 US10099993, Compound 186

SMILES: Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O

InChI Key: InChIKey=HCVBFHIOWLPACE-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 290601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM290601 (US10099993, Compound 186) Show SMILES Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O Show InChI InChI=1S/C23H29NO4/c1-17-21(27-14-6-7-15-28-22-10-4-5-13-24-22)12-11-19(23(17)26)20(25)16-18-8-2-3-9-18/h4-5,10-13,18,26H,2-3,6-9,14-16H2,1H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute US Patent									US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM290601 (US10099993, Compound 186) Show SMILES Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O Show InChI InChI=1S/C23H29NO4/c1-17-21(27-14-6-7-15-28-22-10-4-5-13-24-22)12-11-19(23(17)26)20(25)16-18-8-2-3-9-18/h4-5,10-13,18,26H,2-3,6-9,14-16H2,1H3	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	7.3	25
Sanford-Burnham Medical Research Institute US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair