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BDBM290601 US10099993, Compound 186

SMILES: Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O

InChI Key: InChIKey=HCVBFHIOWLPACE-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 290601   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM290601
PNG
(US10099993, Compound 186)
Show SMILES Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O
Show InChI InChI=1S/C23H29NO4/c1-17-21(27-14-6-7-15-28-22-10-4-5-13-24-22)12-11-19(23(17)26)20(25)16-18-8-2-3-9-18/h4-5,10-13,18,26H,2-3,6-9,14-16H2,1H3
PDB

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UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

US Patent




US Patent US10099993 (2018)


BindingDB Entry DOI: 10.7270/Q2Z89FFP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM290601
PNG
(US10099993, Compound 186)
Show SMILES Cc1c(OCCCCOc2ccccn2)ccc(C(=O)CC2CCCC2)c1O
Show InChI InChI=1S/C23H29NO4/c1-17-21(27-14-6-7-15-28-22-10-4-5-13-24-22)12-11-19(23(17)26)20(25)16-18-8-2-3-9-18/h4-5,10-13,18,26H,2-3,6-9,14-16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/a7.325



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US10099993 (2018)


BindingDB Entry DOI: 10.7270/Q2Z89FFP
More data for this
Ligand-Target Pair