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BDBM291213 N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3,3-dimethylazetidin-1-yl)quinoline-2-carboxamide::US9580418, Example 33::US9890162, Example 33

SMILES: C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1

InChI Key: InChIKey=UURNQJRXOUIRSZ-ZSFWTHPBNA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291213   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/a7.525



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2X92DB9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.50E+3n/an/an/an/a7.525



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2X92DB9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...


US Patent US9890162 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...


US Patent US9890162 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...


US Patent US9890162 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/a7.525



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q2X92DB9
More data for this
Ligand-Target Pair