BDBM291522 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one ::US10413562, Compound A250::US9580449, Example A250::US9580449, Example A39

SMILES: Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=QUIWHXQETADMGN-UHFFFAOYSA-N

Data: 1 KI  23 IC50  9 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 291522   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	7.5	27
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Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet glycoprotein VI (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Early activation antigen CD69 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Tec (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	27
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Tec (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase Tec (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM291522 (US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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