BDBM291687 N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 2::US9580437, Example 2

SMILES: Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key: InChIKey=XLIBABIFOBYHSV-UHFFFAOYSA-N

Data: 26 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 291687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2D6 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A5 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Synaptic vesicular amine transporter (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M2 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2A adrenergic receptor (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	8.0	n/a
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					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polycomb protein EED (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Human)	BDBM291687 (US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair