BDBM291690 N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(6-methoxy-4-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 5::US9580437, Example 5

SMILES COc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=CLWFDFUVIUSTHL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291690   

LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  4.80nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  9.70nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  2.90nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  4.80nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  9.70nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291690(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  2.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent