BDBM291911 8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 226::US9580437, Example 226

SMILES CCOc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=LXAVJONJUUHXQC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291911   

LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  3.90nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  5nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  6.10nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  3.90nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  5nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291911(8-(2-ethoxy-4-methylpyrimidin-5-yl)-N-((5-fluoro-2...)
Affinity DataIC50:  6.10nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent