BDBM293348 US10106508, Compound I-17::US10106508, Example 17 N-(4-Chloro-3-nitrophenyl)-5-(1-ethoxyethoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-17)

SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12

InChI Key InChIKey=AGOVZOXQAPLQHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 293348   

TargetEpidermal growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293348(US10106508, Compound I-17 | US10106508, Example 17...)
Affinity DataIC50: 300nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293348(US10106508, Compound I-17 | US10106508, Example 17...)
Affinity DataIC50: 1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent