BDBM2939 4-(2-cyclopropylethynyl)-5-fluoro-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one::Benzoxazinone deriv. 5a::CHEMBL320078

SMILES Fc1cccc2NC(=O)OC(C#CC3CC3)(c12)C(F)(F)F

InChI Key InChIKey=PQKFTGAJMHDMRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2939   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
S.G.S.I.T.S.

Curated by ChEMBL
LigandPNGBDBM2939(4-(2-cyclopropylethynyl)-5-fluoro-4-(trifluorometh...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM2939(4-(2-cyclopropylethynyl)-5-fluoro-4-(trifluorometh...)
Affinity DataIC50:  78nMpH: 8.2 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed