BDBM294312 US9586948, Example 31

SMILES Cn1cc(NC(=O)c2cccc(n2)-c2cnccc2Cl)c(n1)C(N)=O

InChI Key InChIKey=XVZKDSRWPNHHRA-UHFFFAOYSA-N

Data  3 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294312   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294312(US9586948, Example 31)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2cnccc2Cl)c(n1)C(N)=O
Show InChI InChI=1S/C16H13ClN6O2/c1-23-8-13(14(22-23)15(18)24)21-16(25)12-4-2-3-11(20-12)9-7-19-6-5-10(9)17/h2-8H,1H3,(H2,18,24)(H,21,25)
Affinity DataIC50: 620nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294312(US9586948, Example 31)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2cnccc2Cl)c(n1)C(N)=O
Show InChI InChI=1S/C16H13ClN6O2/c1-23-8-13(14(22-23)15(18)24)21-16(25)12-4-2-3-11(20-12)9-7-19-6-5-10(9)17/h2-8H,1H3,(H2,18,24)(H,21,25)
Affinity DataIC50: 683nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294312(US9586948, Example 31)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2cnccc2Cl)c(n1)C(N)=O
Show InChI InChI=1S/C16H13ClN6O2/c1-23-8-13(14(22-23)15(18)24)21-16(25)12-4-2-3-11(20-12)9-7-19-6-5-10(9)17/h2-8H,1H3,(H2,18,24)(H,21,25)
Affinity DataIC50: 683nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full-length IRAK4 expressed in baculovirus infected Sf9 insect cells using 5FAM-RKRQGSVRRRVH-CO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid