BDBM294322 US9586948, Example 41

SMILES Cn1cc(NC(=O)c2cccc(n2)-c2ccnc(NCC3CC3)c2)c(n1)C(=O)N1CCOCC1

InChI Key InChIKey=UVDXCCVBDOELRG-UHFFFAOYSA-N

Data  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294322   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294322(US9586948, Example 41)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2ccnc(NCC3CC3)c2)c(n1)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H27N7O3/c1-30-15-20(22(29-30)24(33)31-9-11-34-12-10-31)28-23(32)19-4-2-3-18(27-19)17-7-8-25-21(13-17)26-14-16-5-6-16/h2-4,7-8,13,15-16H,5-6,9-12,14H2,1H3,(H,25,26)(H,28,32)
Affinity DataIC50: 1.83E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid